Endokrinologie und Diabetesforschung

Metabolism and Metabonomics in Cancer Risk Assessment, Diagnosis, Prognosis and Treatment

M. Čuperlović-Culf

Metabolism and Metabonomics in Cancer Risk Assessment, Diagnosis, Prognosis and Treatment

Cancer is a genetic disease – changes to the cell’s DNA lead to malignant transformation and known hallmarks of cancer. Genetic or epigenetic mutations leading to altered expression levels and activation of oncogenes and oncosuppressor genes reprogram metabolism as well and this further promotes tumor progression. There are now many experimental and clinical proofs of the significance of cancer metabolic phenotype in cancer’s development, growth and metastasis.