Zeitschrift für Regenerative Medizin

Literature Review on Recent Clinical Studies Using Autologous Human Adult Stem Cells and Induced Pluripotent Stem Cells

HO Y and Al Shammary S

Stem cell-based therapy has emerged as a promising approach for the treatment of various diseases and injuries, and novel strategies are actively implemented to optimize the safety and efficacy of the therapies. As the clinical applications become increasingly diverse, there is a growing need for the integration of findings from numerous transplantation studies to assess the current status of stem cell-based interventions. This review outlines the recent progress, focusing on the use of autologous adult stem cells and induced pluripotent stem cells in human clinical studies. The survey of the current literature on stem cell transplantations shows that considerable efforts have been made to address determinants of therapy efficacy such as cell types and delivery routes. Analysis of clinical applications reveals a trend for studies involving nervous,cardiovascular, and skeletal systems. Applications across diverseorgan systems are also evident, confirming the versatility of stemcells in a wide variety of clinical contexts.