Zeitschrift für Regenerative Medizin

A combined use of Chondrocytes Micro Grafts (CMG) Mixed with Platelet Rich Plasma (PRP) in Patients Affected by Pinch Nose Deformity

Gentile P, Scioli MG, Bielli A, Orlandi A, Cervelli V

Background: The combined use of autologous chondrocytes micro-grafts (CMG) mixed with Platelet Rich Plasma (PRP) is an alternative that opens a new era in this field.

Materials and Methods: At the Department of Plastic and Reconstructive Surgery, University of Rome “Tor Vergata”, Italy, 15 patients, affected by pinch nose deformity underwent nasal alar reconstruction with chondrocytes micro-grafts gentle poured onto PRP in solid form. A CT scan control was performed after 12 months. Pearson’s Chi-square test was used to investigate difference in cartilage density (CD) between native and newly formed cartilage.

Results: The constructs of CMG-PRP subcutaneously injected resulted in cartilage tissue with adequate central nutritional perfusion. Postoperative follow-up evaluation has shown optimal aesthetic results and improvement of nasal obstruction. These composite grafts provide functional support to the alar cartilages, usually collapsed in pinch nose deformity because of excessive resection during previous surgery.

Conclusion: This report demonstrated that chondrocytes micrografts derived from nasal septum poured onto PRP in solid form are a useful method for cartilage regeneration in patients affected by external nasal valve collapse.