Internationale Zeitschrift für Herz-Kreislauf-Forschung

Molecular Strategies Contributing to Efficient Homing of Bone Marrow Stem Cells

Fatemeh Pourrajab, Seyed Khalil Forouzannia, Seyed Hossain Hekmatimoghadamand Marjan Tajik kord

Molecular Strategies Contributing to Efficient Homing of Bone Marrow Stem Cells

For successful systemic stem cell therapy, BMSCs must transmigrate across the endothelium and invade their target tissue.A prerequisite for a successful usage of BMSCs is that they exit the blood circulation via transmigration and invasion. The endothelial phenotype selectively modulates BMSCs transmigration and morphological changes. BMSCs exit the blood circulation by integrating into the endothelium, penetrating the basement membrane and invading the surrounding tissue via the formation of plasmic podia.