Internationale Zeitschrift für Herz-Kreislauf-Forschung

Increased pro-Oxidant- Antioxidant Balance in Patients with Diabetes Mellitus

Seyed Reza Mirhafez, Amir Avan, Raheleh Darsouie, Alireza Heidari-Bakavoli, Seyed Mohammad Reza Parizadeh,Mohsen Mazidi, Hossein Savadi, Mahmoud Ebrahimi,Gordon A Ferns and Majid Ghayour-Mobarhan

 Increased pro-Oxidant– Antioxidant Balance in Patients with Diabetes Mellitus

Background: Diabetes mellitus (DM) is a common metabolic condition affecting populations globally. Diabetes mellitus is associated with an imbalance between pro-oxidant mechanisms and the antioxidant defenses, contributing to oxidative-stress, and this is associated with an increased susceptibility to endothelial dysfunction, atherosclerosis, insulin-resistance and impairedpancreatic β-cell function. Here we have investigated the serum pro-oxidant/antioxidant balance (PAB) in the patients with diabetes and healthy subjects. Methods: Serum PAB was assessed in 658 subjects, comprised of 69 patients with diabetes, 81 subjects with impaired fasting glucose (IFG) and 508 healthy-subjects. Results: The diabetic patients had significantly higher fasting blood glucose (FBG) and serum triglycerides (TG), compared to subjects with IGT IFG and healthy individuals. Median serum PAB values were significantly higher in the patients with diabetes (92.03 [interquartile-range [IQ]: 31.40-124.56]) compared to the healthy group (48.1 [IQ: 20.6-85.9]; P<0.05). Multivariate-linear-regression model and binary-regression-logistic analysis showed that PAB, FBG and TG were significantly associated with DM. Conclusion: In diabetics there is an imbalance between serum pro-oxidant and antioxidant activity. Furthermore, our findings indicate that this assay could be used along with other risk factors to estimate the oxidative stress in high-risk patients.