Journal of Primary & Acquired Immunodeficiency Research

Evaluation of Growth and Bone Metabolism in Adolescent Patients with Common Variable Immunodeficiency

Necil Kutukculer, Damla Goksen, Nesrin Gulez, Neslihan E. Karaca, Guzide Aksu and Sukran Darcan

Evaluation of Growth and Bone Metabolism in Adolescent Patients with Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, resulting in increased susceptibility to infections and diminished responses to protein and polysaccharide vaccines. Most common infections are sinopulmonary caused by Streptococcus pneumonia, Haemophilus influenza, Klebsiella pneumonia and sometimes mycoplasma. An intrinsic B cell defect; inability to differentiate to plasma cells and secrete immunoglobulins, has been most commonly observed in terms of pathogenesis. Many defects in T cells have also been noted in patients with CVID.