Zeitschrift für Meeresbiologie und Ozeanographie

Marine Organism Derived Enzyme Inhibitors

Joseph Arvello

Enzyme inhibitors are a vital subject of study because they help us to learn more about enzymes and proteins, as well as pathways and their regulatory networks. Many enzyme inhibitor surveys are intended to identify novel bioactive chemicals, precursors, or medications themselves, therefore there is often an applied side to this research. These efforts can be approached in a variety of ways, including metabolite screening of known producer organisms while altering their growth or environment, direct environmental metabolite screening of rich habitats, screening of related strains or species of known producers, sampling complex cultures or habitats, in silico screening of genomes and metagenomes, cloning or manipulating efforts of secondary metabolite gene clusters, docking molecules or libraries into tetrahedrons, and docking molecules or libraries.