Gutachten zur Umweltbiologie

E-cigarette Vape and Lung ACE2 Expression

Shen Mark

Evidence in human beings indicates a correlation among nicotine smoking and extreme respiration signs and symptoms with COVID-19 contamination. In lung tissue, angiotensin-changing enzyme 2 (ACE2) seems to mechanistically underlie viral entry. Here, we investigated whether or not e-cigarette vapour inhalation alters ACE2 and nicotinic acetylcholine receptor (nAChR) expression in male and woman mice. In male lung, nicotine vapour inhalation triggered a sizable growth in ACE2 mRNA and protein, however surprisingly, those variations had been now no longer located in females.