Forschungsjournal für klinische Dermatologie

Daphne Laureola extract for the topical efficaceous treatment of the Psoriasic Plaques

Donatella Paolino

Psoriasis is a chronic, multifactorial disorder, influenced by both genetic and environmental factors of the skin. It generally have a significant negative impact on the physical, emotional, and, psychosocial wellbeing of affected patients. It may presents several clinical cutaneous manifestations, but most commonly it presents plaques (that effects 80% of patients and that mostly conditionate at social level them).      

Daphne laureola L., (Italian: dame laurella), is a species of Daphne, of the Thymelaeaceae family. Its aqueous extract showed interesting profile for the topical treatment of the psoriasis plaques. It demostrated an excellent activity both in vitro (reducing the hyperproliferation of human fibrobalsts in a suitable in vitro model) and in vivo on patients affected by psoriasis plaques. In particular a gel based on Dafne Laureola extract, was applied topically by 90, selected patients affected by moderate and severe psoriasis plaques. The gel, applied twice a day, led to the complete reduction of psoriasis plaques in an average period of 20 days. At the complete remission of the plaques, the treatment was applied one a day for a period of 30 days, the 95% of the treated patients didn’t develope plaques for a minimun period of two years.

The proposed treatment represents a suitable remedy to relieve the symptomatology of the psoriasis and in particular to reduce the presence of plaques, very often responsible of social and emotional negative impacts.