Lynnette Wei-Hsien Koh, Tan Boon Toh, Yuk Kien Chong, Edwin Sandanaraj, Beng Ti Ang and Carol Tang
Signalling Pathways in Glioma-Propagating Cells
TGlioblastomas (GBMs) are highly aggressive and malignant brain tumors and have poor prognosis despite advanced surgical resections accompanied by chemo-radiation interventions.Current therapeutic advances remain essentially palliative, with modest amelioration in clinical response, due largely to the acquired resistance of GBM cells to conventional chemoradiation therapies. The cellular and molecular heterogeneity of GBMs highlights a complex interplay of individual mechanisms that contribute to varied patient treatment response.
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