Zeitschrift für klinische und experimentelle Onkologie

p53 Gene Inactivation Modulate Methylenetetrahydrofolate C677T Gene Polymorphism Associated Risk Factor for the Development of Cervical Carcinoma -A Tissue specific Genetic Heterogeneity

GK Singh, Ajit K Saxena, Anjula, Garima, S Pandey and LK Pandey

p53 Gene Inactivation Modulate Methylenetetrahydrofolate C677T Gene Polymorphism Associated Risk Factor for the Development of Cervical Carcinoma -A Tissue specific Genetic Heterogeneity

Inconsistently, epidemiological studies reveals that folate regulate a significant role in DNA synthesis and etiopathology of cervical cancer in women. Folate, an essential dietary component require for DNA methylation during cell proliferation. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methylenetetrahydrofolate involved in the methylation of homocysteine to methionine. A common substitution of this enzyme gene variant 677 C → T (Ala → Val) shown to reduced activity results mild hyperhomocysteinemia. We have collected the blood sample from those patients having lack of infection form human papilloma virus (HPV).