Zeitschrift für Angewandte Bioinformatik und Computational Biology

Speeding Up Large-Scale Next Generation Sequencing Data Analysis with pBWA

Darren Peters, Xuemei Luo, Ke Qiu and Ping Liang

Speeding Up Large-Scale Next Generation Sequencing Data Analysis with pBWA

Newly available DNA sequencing technologies can generate billions of DNA sequences in a single machine run, making it feasible to obtain an individual’s entire genome sequences very quickly and at a very affordable cost. These personal genome sequences can be used to identify genetic variations associated with variable traits, but they must first be aligned to a reference genome sequence using computer algorithms that make use of approximate string matching methods.