Sheila K. Pirooznia and Felice Elefant
Modulating Epigenetic HAT Activity: A Promising Therapeutic Option for Neurological Disease?
The epigenome (epi- derived from Greek for ‘over’ or ‘above’) with its rich cache of highly regulated structural modifications to the DNA, histone residues and histone variants, defines the threedimensional structure of chromatin, the genetic material within the eukaryotic cell nucleus, and serves as the molecular bridge between transcriptional gene control and our environment.
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