Zeitschrift für Infektionskrankheiten und Immuntherapien

Microbiology Congress 2018: Structure-based virtual screening to identify the lactamase CTX-M-9 inhibitors: An in silico effort to overcome antibiotic resistance in E. Coli - Sako Mirzaie - Islamic Azad University

Sako Mirzaie

Recently, the quick spreads of broad-spectrum β-lactams antibiotic resistance in pathogenic strains of bacteria has become a major global health problem. These new emerging resistances cause ineffectiveness of antibiotics and increasing the severity of diseases and treatment costs. Among different and diverse resistance targets, we chose a class-A β-lactamase, CTX-M-9, with the aim of identifying new chemical entities to be used for further rational drug design. Based on this purpose, a set of 5000 molecules from the Zinc database have been screened by docking experiments using AutoDock Vina software.